ANTIBODIES AND IGG FUSION PROTEINS WITH AN EXTENDED HALF-LIFE

The present invention provides antibodies or IgG Fc fusion proteins comprising a canine or feline fragment crystallizable region (Fc region) that has an enhanced half-life due to one or more specific amino acid substitutions in the Fc region. The increased half-life can be a function of an increased...

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Bibliographic Details
Main Authors STAUFFER, Seth D, MORSEY, Mohamad
Format Patent
LanguageEnglish
French
German
Published 26.06.2024
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention provides antibodies or IgG Fc fusion proteins comprising a canine or feline fragment crystallizable region (Fc region) that has an enhanced half-life due to one or more specific amino acid substitutions in the Fc region. The increased half-life can be a function of an increased binding affinity for a neonatal Fc receptor (FcRn) at moderately acidic pH relative to that of corresponding antibody or IgG Fc fusion protein that comprises an unsubstituted canine or feline Fc region. Pharmaceutical compositions that comprise these antibodies and/or IgG fusion proteins are also provided.
Bibliography:Application Number: EP20220768645