FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY

Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen...

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Bibliographic Details
Main Authors DILUZIO, Willow, BROWN, Jason, VARGA, Csanad M, NGUYEN, Phuong M, SCHOLZ, Catherine, JENKINS, Erica Helen, PALANIAPPAN, Vaithianathan, FOX, Irving H, ROSARIO, Maria
Format Patent
LanguageEnglish
French
German
Published 04.09.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
Bibliography:Application Number: EP20240167547