RECOMBINANT ANTIGEN FOR INDUCING AN IMMUNE RESPONSE AGAINST THE ZIKA VIRUS

• Main Authors: ROMERO FERNÁNDEZ, Yaremis, PÉREZ FUENTES, Yusleidi, de la Caridad, BRUNO DARDER, Andy, Jesús, HERMIDA CRUZ, Lisset, VALDÉS PRADO, Iris, GIL GONZALEZ, Lázaro, COBAS ACOSTA, Karem, SUZARTE PORTAL, Edith, LAZO VÁZQUEZ, Laura, GUILLEN NIETO, Gerardo, Enrique
• Format: Patent
• Language: English; French; German
• Published: 05.06.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a recombinant chimeric antigen comprising, in the polypeptide chain thereof, a polypeptide corresponding to amino acids 2 to 104 of the Zika virus capsid protein or a polypeptide with an amino acid sequence with at least 90% identity with said region of the capsid protein. The invention also relates to a vaccine composition comprising said recombinant chimeric antigen and a pharmaceutically acceptable vaccine adjuvant. The invention further relates to the use of the recombinant chimeric antigen, comprising, in the polypeptide chain thereof, a polypeptide corresponding to amino acids 2 to 104 of the Zika virus capsid protein or an amino acid sequence with at least 90% identity with said segment for the production of a drug for inducing an immune response against the Zika virus. The invention also discloses a method for inducing an immune response against the Zika virus, in which the recombinant chimeric antigen is administered.