METHOD FOR PRODUCING ARYLAMIDE DERIVATIVE
The present disclosure provides, for example, a method for producing 2-(4-cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[[3-fluoro-2-(methylsu lfamoylamino)pyridin-4-yl]methyl]benzamide or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt, the...
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Main Authors | , |
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Format | Patent |
Language | English French German |
Published |
29.05.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The present disclosure provides, for example, a method for producing 2-(4-cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[[3-fluoro-2-(methylsu lfamoylamino)pyridin-4-yl]methyl]benzamide or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt, the method comprising reacting (2-amino-3-fluoropyridin-4-yl)methanol with methyl chloroformate and N,N-dimethylaminopyridine in acetonitrile to give (2-amino-3-fluoropyridin-4-yl)methyl methyl carbonate. According to the present disclosure, there is provided a method for producing a specific aryl amide derivative that has RAF/MEK complex-stabilizing activity and/or MEK-inhibiting activity and is useful for the treatment or prevention of a cell proliferative disorder, particularly a cancer, the method enabling the aryl amide derivative to be produced with a small number of steps. |
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Bibliography: | Application Number: EP20220845947 |