PI3Ka INHIBITORS AND METHODS OF USE THEREOF

• Main Authors: DIPIETRO, Lucian V, MCLEAN, Thomas H, FRIDRICH, Cary Griffin, PAN, Yue, MOHAMED, Tarek, PIERCE, Levi Charles Thomas, GELOZIA, Shorena, BURNIE, Andrew J, VEMULA, Naresh, ATIENZA, Bren-Jordan, LARIVEE, Alexandre, MEDENA, Caleb, MADER, Mary M, TAYLOR, Alexander M, BOEZIO, Alessandro, LEPITRE, Thomas, DENINNO, Michael Paul, PAL, Mohan, TANVEER, Kashif, KURUKULASURIYA, Ravi, MAERTENS, Gaetan, GUNAYDIN, Hakan
• Format: Patent
• Language: English; French; German
• Published: 22.05.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure.