BIOLOGICAL PARTICLE ENRICHMENT APPARATUS AND PICO-DROPLET GENERATOR THEREOF

• Main Authors: HUANG, Chung-Er, HO, Hsin-Cheng, YE, Guang-Ci, CHEN, Sheng-Wen
• Format: Patent
• Language: English; French; German
• Published: 01.05.2024
• Subjects: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; TESTING; TRANSPORTING

A biological particle enrichment apparatus (2) and a pico-droplet generator (21) thereof are provided. The pico-droplet generator (21) includes a container (211), a hollow needle (212) connected to the container (211), a first piezoelectric member (213) disposed on the container (211), and a second piezoelectric member (214) disposed on the hollow needle (212). The container (211) can receive a liquid specimen (200) having biological particles (201). The hollow needle (212) and the container (211) are fluid communicated with each other, and an inner diameter (D211) of the container (211) is within a range from 5 times to 30 times of an inner diameter (D212) of the hollow needle (212). The first piezoelectric member (213) is annularly disposed on a surrounding lateral side (2112) of the container (211), and enables the biological particles (201) in the container (211) to move along a direction away from the surrounding lateral side (2112) by vibrating the container (211). The second piezoelectric member (214) can squeeze the hollow needle (212), so that the liquid specimen (200) flows outwardly to form a pico-droplet (202).