MULTISTEP PROCESS FOR CULTURING TUMOR-INFILTRATING LYMPHOCYTES FOR THERAPEUTIC USE

The present invention is targeted towards depleting suppressive cells, including regulatory T cells, and/or reinvigorating exhausted Tumor Infiltrating Lymphocytes (TILs) in vitro by co-culturing excised TIL containing tumor fragments (or tumor digest) with Tumor Microenvironment (TME) Stimulators,...

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Bibliographic Details
Main Authors HEEKE, Christina, KIRKETERP-MØLLER, Nikolaj, CORDES, Ulrik, FRIESE, Christina
Format Patent
LanguageEnglish
French
German
Published 24.04.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention is targeted towards depleting suppressive cells, including regulatory T cells, and/or reinvigorating exhausted Tumor Infiltrating Lymphocytes (TILs) in vitro by co-culturing excised TIL containing tumor fragments (or tumor digest) with Tumor Microenvironment (TME) Stimulators, such as Immune Checkpoint Inhibitors (ICIs), Cytokines/interleukins, and/or inhibiting the effect of regulatory T cells secreted factors (such as inhibiting IL-10) thereby creating a favorable tumor microenvironment where inhibitory T-cells and/or signals are removed so that exhausted T-cells can expand faster, to higher numbers, and are more potent than currently established TIL expansion protocols. A time lapse of the use of TME stimulators is of interest.
Bibliography:Application Number: EP20220734940