T CELL ENGAGER MOLECULES AND USES THEREOF

The present invention provides single chain T cell engager (TCE) molecules having an scFab that binds a target antigen and an scFv that binds CD3, and TCE molecules that bind CCR8 and CD3. Methods of treating cancer are also provided.

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Bibliographic Details
Main Authors RAUM, Tobias, PIERCE, Nathan, William, BROZY, Johannes, CHEN, Wentao, PENDZIALEK, Jochen, S, KIELCZEWSKA, Agnieszka, BLUEMEL, Claudia, MUENZ, Markus, WINKEL, Lisa, DAHLHOFF, Christoph, HONER, Jonas, Karl-Josef, BATES, Darren, L
Format Patent
LanguageEnglish
French
German
Published 10.04.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides single chain T cell engager (TCE) molecules having an scFab that binds a target antigen and an scFv that binds CD3, and TCE molecules that bind CCR8 and CD3. Methods of treating cancer are also provided.
Bibliography:Application Number: EP20220734448