TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN)

The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutica...

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Main Authors ZHANG, Sisi, MOEBITZ, Henrik, NOCITO, Sandro, GOGNIAT, Geoffrey, GONG, Wanben, SOTO, Jessica, HOLZER, Philipp, SCHOEPFER, Joseph, ZECRI, Frédéric, BORDAS, Vincent, FUREGATI, Markus, LIMAM, Fatma, YU, Huangchao, YAO, Shuping, STRANG, Ross, HAMON, Jacques, BRUN, Jvan, SCHMIEDEBERG, Niko, DECKER, Andrea, HINRICHS, Juergen Hans-Hermann, PLATTNER, Simone
Format Patent
LanguageEnglish
French
German
Published 10.04.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.
Bibliography:Application Number: EP20220729790