TOLEBRUTINIB SALT AND CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF
This application relates to the chemical field of medicine, specifically to tolebrutinib salts and their crystal forms, their preparation methods, their pharmaceutical compositions, and their uses. Tolebrutinib hydrochloride and its crystal form provided in this application have at least one advanta...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | English French German |
Published |
27.03.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | This application relates to the chemical field of medicine, specifically to tolebrutinib salts and their crystal forms, their preparation methods, their pharmaceutical compositions, and their uses. Tolebrutinib hydrochloride and its crystal form provided in this application have at least one advantage: good stability, low hygroscopicity, solubility meeting medicinal requirements, uniform particle size distribution, good morphology, good flowability, good compressibility, good crystallinity, good storage stability, avoiding phase transformation during drug development and storage, simple and reliable preparation method, and great development value. The tolebrutinib maleate and its crystal form of this application have at least one advantage: good stability, uniform particle size distribution, good flowability, solubility meeting pharmaceutical requirements, good storage stability, avoiding phase transformation during drug development and storage, and simple and reliable preparation method. |
---|---|
Bibliography: | Application Number: EP20220804060 |