PHARMACEUTICAL COMPOSITION COMPRISING IBRUTINIB AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE

The present invention relates to a pharmaceutical composition comprising ibrutinib as an effective ingredient for preventing or treating degenerative brain disease. Ibrutinib according to the present invention inhibits the activity of microglias or astrocytes to suppress the damage of activated micr...

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Bibliographic Details
Main Authors Kang, RI JIN, Hoe, Hyang Sook, Lee, Ju Young, Nam, Young Pyo, Nam, Hye Yeon, Kim, Jeoung Yeon, Lee, Hyun Ju
Format Patent
LanguageEnglish
French
German
Published 29.05.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a pharmaceutical composition comprising ibrutinib as an effective ingredient for preventing or treating degenerative brain disease. Ibrutinib according to the present invention inhibits the activity of microglias or astrocytes to suppress the damage of activated microglias or activated astrocytes on neurons, exhibits the excellent effect of restraining the lipopolysaccharide (LPS)-induced migration of microglias, has the activity of reducing amyloid plaques and inhibiting the phosphorylation of tau proteins, and enhances memory and learning capability and thus can be used as a therapeutic agent for prevention or treatment of degenerative brain disease
Bibliography:Application Number: EP20230206941