METHOD FOR CONSTRUCTING VARIATION LITERATURE INTERPRETATION KNOWLEDGE BASE, AND INTERPRETATION METHOD AND ELECTRONIC DEVICE

• Main Authors: LI, Ning, ZENG, Quanlei, HUANG, Daoling, YUAN, Yuying, LIU, Shuixia, XIONG, Yun
• Format: Patent
• Language: English; French; German
• Published: 07.02.2024
• Subjects: CALCULATING; COMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS; COMPUTING; COUNTING; ELECTRIC DIGITAL DATA PROCESSING; PHYSICS

Provided are an NLP-based method for constructing a variant literature interpretation knowledge base, and an interpretation method and an electronic device. The method for constructing the variant literature interpretation knowledge base includes: obtaining disease-related literature; constructing, based on the disease-related literature, a database of entities associated with genes and variants; constructing a literature evidence knowledge graph for interpretation of variant literature; and performing evidence extraction on the literature evidence knowledge graph to obtain evidence corresponding to an entity, and constructing, based on the evidence and the database, the variant literature interpretation knowledge base. In this way, the literature evidences can be more comprehensive and systematic. Thus, during interpretation, evidence standard or evidence type result based on literature reading can be automatically returned upon inputting an entity name, thereby achieving the automation and intelligence for obtaining disease variant literature evidence, and the interpretation speed related to genes and variants can be effectively improved.