2,4-DIAMINOPYRIMIDINE OXIDE PREPARATION METHOD

The invention relates to the technical field of synthesis of a heterocyclic compound, and particularly discloses a method for preparing 2,4-diaminopyrimidine oxide. The method includes the steps of: cyclizing 3-oxopropionitrile with guanidine under an oxidizing condition to obtain 2,4-diaminopyrimid...

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Bibliographic Details
Main Authors TAN, Chang, JIAN, Yimin, LI, Teng, TENG, Xin, ZHANG, Haoqian
Format Patent
LanguageEnglish
French
German
Published 07.02.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to the technical field of synthesis of a heterocyclic compound, and particularly discloses a method for preparing 2,4-diaminopyrimidine oxide. The method includes the steps of: cyclizing 3-oxopropionitrile with guanidine under an oxidizing condition to obtain 2,4-diaminopyrimidine oxide, wherein the 3-oxopropionitrile is obtained by oxidizing 3-hydroxypropionitrile, which is a cheap and easily available pharmaceutical chemical, as a raw material. The method of the present invention is green and mild, realizing the synthesis of Aminexil from a simple, cheap and easily available raw material.
Bibliography:Application Number: EP20220928065