RITUXIMAB-RESISTANT CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD 19 antigen binding domain that specifically binds to CD 19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of makin...

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Bibliographic Details
Main Authors PERTEL, Thomas Charles, SASU, Barbra Johnson, LEONARD, Mark W
Format Patent
LanguageEnglish
French
German
Published 14.02.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD 19 antigen binding domain that specifically binds to CD 19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using these CD 19-specific CARs, and immune cells comprising these CD19-specific CARs.
Bibliography:Application Number: EP20230186544