VESICLES AND USES THEREOF

The present disclosure provides synthetic eukaryotic vesicles (SyEVs) prepared from exosomes secreted by eukaryotic cells. The exosomes have been exposed to a mild alkaline pH to expel the cytoplasmic components present in the exosomes while retaining native structure of cell surface proteins, such...

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Bibliographic Details
Main Authors BERGQVIST, Markus, PARK, Kyong-su, LÖTVALL, Jan
Format Patent
LanguageEnglish
French
German
Published 29.11.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides synthetic eukaryotic vesicles (SyEVs) prepared from exosomes secreted by eukaryotic cells. The exosomes have been exposed to a mild alkaline pH to expel the cytoplasmic components present in the exosomes while retaining native structure of cell surface proteins, such as, integrins. The present disclosure provides extruded ghost nanovesicles (exgNVs) loaded with an anti-inflammatory agent. These exgNVs enhance the anti-inflammatory effect of the anti-inflammatory agent. Methods of making such SyEVs and exgNVs and therapeutic uses of such SyEVs and exgNVs are also provided. The SyEVs and exgNVs may be produced from a human cell line genetically modified to express lymphocyte function-associated antigen-1 (LFA-1), where LFA-1 is located on surface of the SyEVs and exgNVs.
Bibliography:Application Number: EP20220767913