PHARMACEUTICAL COMPOSITION

• Main Authors: FERRAND, Maria Dimitrova, BOBICHON, Julien, LAHAYE, Vincent
• Format: Patent
• Language: English; French; German
• Published: 25.10.2023
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The present invention provides a pharmaceutical composition comprising(a) a triblock copolymer having the formula:         PLAv-PEGw-PLAxwherein v and x are the number of repeat units ranging from 1 to 3,000 and w is the number of repeat units ranging from 3 to 300 and v=x or v≠x in an amount of 22 to 34 w/w % of the total composition;(b) a diblock copolymer having the formula:         mPEGy-PLAzwherein y and z are the number of repeat units with y ranging from 2 to 250 and z ranging from 1 to 3,000 in an amount of 5 to 9 w/w% of the total composition;(c) tacrolimus or a pharmaceutically acceptable salt thereof in an amount of 8 to 32 w/w % of the total composition; and(d) organic solvent in an amount of 30 to 62 w/w % of the total composition.