SUBSTITUTED PYRAZOLO PIPERIDINE CARBOXYLIC ACIDS

• Main Authors: SANDNER, Peter, WEBSTER, Robert, Alan, STELLFELD, Timo, BOULTADAKIS-ARAPINIS, Melissa, MATHAR, Ilka, COLLIN-KRÖPELIN, Marie-Pierre, DIETZ, Lisa, SCHMECK, Carsten, WUNDER, Frank, MONDRITZKI, Thomas, HOFMEISTER, Lucas, Hudson, DIESKAU, Andre, CANDISH, Lisa, VAKALOPOULOS, Alexandros, ORTEGA HERNANDEZ, Nuria
• Format: Patent
• Language: English; French; German
• Published: 18.10.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).