SUBSTITUTED PYRAZOLO PIPERIDINE CARBOXYLIC ACIDS

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure...

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Main Authors SANDNER, Peter, WEBSTER, Robert, Alan, STELLFELD, Timo, BOULTADAKIS-ARAPINIS, Melissa, MATHAR, Ilka, COLLIN-KRÖPELIN, Marie-Pierre, DIETZ, Lisa, SCHMECK, Carsten, WUNDER, Frank, MONDRITZKI, Thomas, HOFMEISTER, Lucas, Hudson, DIESKAU, Andre, CANDISH, Lisa, VAKALOPOULOS, Alexandros, ORTEGA HERNANDEZ, Nuria
Format Patent
LanguageEnglish
French
German
Published 18.10.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
Bibliography:Application Number: EP20210820285