CLDN18.2 ANTIBODY AND USE THEREOF

Provided are an antibody or antigen-binding fragment thereof, and a chimeric antigen receptor, which have the ability of specifically recognizing CLDN18.2. The antibody, antigen-binding fragment, or chimeric antigen receptor comprises at least one CDR sequence selected from the following or an amino...

Full description

Saved in:
Bibliographic Details
Main Authors WANG, Xufang, REN, Zhiheng, CHEN, Xiaofeng, XU, Le, LI, Wenjia, ZHAO, Guanghui, JIANG, Yan, ZHANG, Kuo, YU, Tingting, YE, Qunrui, FENG, Liya, DONG, Junji
Format Patent
LanguageEnglish
French
German
Published 04.10.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:Provided are an antibody or antigen-binding fragment thereof, and a chimeric antigen receptor, which have the ability of specifically recognizing CLDN18.2. The antibody, antigen-binding fragment, or chimeric antigen receptor comprises at least one CDR sequence selected from the following or an amino acid sequence having at least 95% identity therewith: the CDR sequences of light chain variable region shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 7, SEQ ID NO: 8 and SEQ ID NO: 9; the CDR sequences of heavy chain variable region shown in SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 11 and SEQ ID NO: 12.
Bibliography:Application Number: EP20210897133