ARGINASE 1 BINDERS FOR INHIBITING ARGINASE 1 ACTIVITY

Arginase 1 binders comprising human antibodies and antigen-binding fragments thereof that inhibit the activity of human Arginase 1 (hArg1) are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in...

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Bibliographic Details
Main Authors FAYADAT-DILMAN, Laurence, SHAHEEN, Hussam Hisham, BAILLY, Marc Andre, CHAKRAVARTHY, Kalyan, KOFMAN, Esther, O'NEIL, Jennifer, E, FAYAD, Ghassan Najib, LIN, Heping, SCAPIN, Giovanna, JUAN, Veronica, PALTE, Rachel Lynn, WANG, Tao
Format Patent
LanguageEnglish
French
German
Published 04.10.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Arginase 1 binders comprising human antibodies and antigen-binding fragments thereof that inhibit the activity of human Arginase 1 (hArg1) are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.
Bibliography:Application Number: EP20210898970