POLY ACRYLATE AND POLY(BETA-ESTER) CAPSULES WITH ENHANCED DEGRADABILITY
Delivery particles encapsulating oily core materials have a shell material of hybrid poly acrylate and poly(beta-amino esters) (PAC/PBAE). The delivery particles may have a single shell of hybrid PAC/PBAE, dual shells including hybrid PAC/PBAE in an inner shell and PBAE in an outer shell crosslinked...
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Main Author | |
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Format | Patent |
Language | English French German |
Published |
27.09.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Delivery particles encapsulating oily core materials have a shell material of hybrid poly acrylate and poly(beta-amino esters) (PAC/PBAE). The delivery particles may have a single shell of hybrid PAC/PBAE, dual shells including hybrid PAC/PBAE in an inner shell and PBAE in an outer shell crosslinked to the inner shell, or multiple shells including PAC in an inner shell, hybrid PAC/PBAE in a transitioning shell, and PBAE in an outer shell. Formation of the delivery particles includes polymerization between multifunctional amine and multifunctional acrylate to produce a water soluble PBAE; polymerization between the preformed PBAE prepolymer having free methacrylate moieties reactive with a multifunctional (meth)acrylate in the oil phase, or at an interface of the water and oil phases to produce PAC wall, polymerization between polyacrylate and the amine moiety of PBAE prepolymer to produce hybrid PAC/PBAE delivery particle wall; and polymerization between multifunctional acrylate and primary or secondary amine moiety of the PBAE prepolymer to form a PBAE outer shell. |
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Bibliography: | Application Number: EP20210895568 |