BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF

Provided herein are compounds of formula (1):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound...

Full description

Saved in:
Bibliographic Details
Main Authors KUROSAKI, Toshio, MAKINO, Takuya, KOIZUMI, Yuka, YAMAKI, Susumu, KURIWAKI, Ikumi, HONJO, Eriko, EVANS, Chris, LU, Pu-Ping, TSUCHIYA, Kazuyuki, WANG, Wenyue, SEKIOKA, Ryuichi, COLLIBEE, Scott, MORGAN, Bradley P, YAMASAKI, Makoto, KATOH, Naoto
Format Patent
LanguageEnglish
French
German
Published 13.09.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Provided herein are compounds of formula (1):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.
Bibliography:Application Number: EP20210815833