CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF

CFTR modulator compounds and compositions including said compounds are provided. The present disclosure also provides PDE4 inhibiting compounds and compositions including said compounds. Also provided are methods of using said compounds and compositions for modulating CFTR, methods for treating an e...

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Main Authors LEE, Jooyun, LEE, Jung Woo, LEE, Seolhee, SOHN, Te-ik, OH, Changmok, LEE, Myongjae, KIM, Gunhee, KWON, Jinsun, YOON, Jongmin, LIM, Dami, PARK, Joontae, RYU, Jaeeun, KIM, Jungho, JEONG, Ilji, KIM, Kyeong-a, LEE, Jin Hee, YOON, Hongchul, AN, Kyung Mi, JUN, Yearin
Format Patent
LanguageEnglish
French
German
Published 06.11.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:CFTR modulator compounds and compositions including said compounds are provided. The present disclosure also provides PDE4 inhibiting compounds and compositions including said compounds. Also provided are methods of using said compounds and compositions for modulating CFTR, methods for treating an eye disease or disorder and methods for treating CFTR-related indications. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE4, for treating an inflammatory disease or disorder and for treating other PDE4-related indications. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.
Bibliography:Application Number: EP20210882228