HIGH AFFINITY BINDERS OF PROTEINS OF THE ATG8 FAMILY

The present invention relates to (poly)peptides comprising a sequence consisting of a LC3-interacting region (LIR) core motif and specific linker peptidic sequences. These (poly)peptides selectively bind, with high affinity, protein(s) of the ATG8 family, and can advantageously be used for the captu...

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Bibliographic Details
Main Authors RODRIGUEZ, Manuel S, QUINET, Grégoire, LEGOUIS, Renaud
Format Patent
LanguageEnglish
French
German
Published 02.08.2023
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The present invention relates to (poly)peptides comprising a sequence consisting of a LC3-interacting region (LIR) core motif and specific linker peptidic sequences. These (poly)peptides selectively bind, with high affinity, protein(s) of the ATG8 family, and can advantageously be used for the capture and/or the detection of protein(s) of the ATG8 family, as well as the identification of autophagy inhibitors.
Bibliography:Application Number: EP20210778488