AMORPHOUS FORM OF ISOQUINOLINE DERIVATIVE

The present invention provides an amorphous form of (S)-2-(3S,8S)-3-(4-(3,4-dichlorobenzyloxy)phenyl-7-((S)-1-phenylpropyl)-2,3,6,7,8,9-hexahydro-[1,4]-dioxino[2,3-g]isoquinolin-8-ylformylamino)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propionic acid dihydrochloride salt, pharmaceutical compositions co...

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Bibliographic Details
Main Authors YOKUM, Thomas Scott, POLISETTI, Dharma Rao, SUN, Yuanqiang, QUADA, JR., James C
Format Patent
LanguageEnglish
French
German
Published 26.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides an amorphous form of (S)-2-(3S,8S)-3-(4-(3,4-dichlorobenzyloxy)phenyl-7-((S)-1-phenylpropyl)-2,3,6,7,8,9-hexahydro-[1,4]-dioxino[2,3-g]isoquinolin-8-ylformylamino)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propionic acid dihydrochloride salt, pharmaceutical compositions comprising the same, methods of preparation and use thereof in treating conditions, such as diabetes, where modulation of the human GLP-1 receptor is beneficial.
Bibliography:Application Number: EP20210870280