PD-1 POLYPEPTIDE VARIANTS

Provided are PD-1 polypeptide variants including an extracellular domain that binds specifically to PD-L1, and a transmembrane domain or a fragment thereof. The disclosure also provides PD-1 Fc fusion proteins including an immunoglobulin Fc region, and a PD-1 polypeptide variant.

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Bibliographic Details
Main Authors SON, Hyun, Tae, LEE, Seunghyun, HAN, Seung, Hee, KWON, Byoung, S, PARK, Jin, Sung, IM, Sun, Woo, LEE, Hanna, CHOI, Jin, Kyung
Format Patent
LanguageEnglish
French
German
Published 06.11.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are PD-1 polypeptide variants including an extracellular domain that binds specifically to PD-L1, and a transmembrane domain or a fragment thereof. The disclosure also provides PD-1 Fc fusion proteins including an immunoglobulin Fc region, and a PD-1 polypeptide variant.
Bibliography:Application Number: EP20210866153