ENGINEERED CAS9-NUCLEASES AND METHOD OF USE THEREOF

Disclosed are SaCas9 protein variants, constructs encoding such variants, compositions comprising such variants and constructs, and methods of using the variants, constructs, and compositions. In some forms, the disclosed variants comprise the mutation Y239H and do not comprise the mutation R245A. A...

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Bibliographic Details
Main Authors YUEN, Tsz Lo, WONG, Siu Lun
Format Patent
LanguageEnglish
French
German
Published 21.06.2023
Subjects
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Summary:Disclosed are SaCas9 protein variants, constructs encoding such variants, compositions comprising such variants and constructs, and methods of using the variants, constructs, and compositions. In some forms, the disclosed variants comprise the mutation Y239H and do not comprise the mutation R245A. Also disclosed are constructs encoding any of the disclosed variants for expression of the variant in a host of interest. Also disclosed are methods of editing a sequence of interest.
Bibliography:Application Number: EP20220214015