ENGINEERED CAS9-NUCLEASES AND METHOD OF USE THEREOF
Disclosed are SaCas9 protein variants, constructs encoding such variants, compositions comprising such variants and constructs, and methods of using the variants, constructs, and compositions. In some forms, the disclosed variants comprise the mutation Y239H and do not comprise the mutation R245A. A...
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Main Authors | , |
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Format | Patent |
Language | English French German |
Published |
21.06.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Disclosed are SaCas9 protein variants, constructs encoding such variants, compositions comprising such variants and constructs, and methods of using the variants, constructs, and compositions. In some forms, the disclosed variants comprise the mutation Y239H and do not comprise the mutation R245A. Also disclosed are constructs encoding any of the disclosed variants for expression of the variant in a host of interest. Also disclosed are methods of editing a sequence of interest. |
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Bibliography: | Application Number: EP20220214015 |