LIPIDIZED COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PEPTIDE ANALOGUES AS ANTI-OBESITY AND NEUROPROTECTIVE AGENTS

The invention provides analogues of the cocaine- and amphetamine-regulated transcript peptide (CARTp) which are anorexigenic compounds that lower food intake and ameliorate metabolic parameters connected with obesity, as well as improve neurodegeneration in brain upon peripheral administration. The...

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Bibliographic Details
Main Authors Pacesova, Andrea, Maletinska, Lenka, Zelezna, Blanka, Strnadova, Veronika, Kunes, Jaroslav
Format Patent
LanguageEnglish
French
German
Published 10.05.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides analogues of the cocaine- and amphetamine-regulated transcript peptide (CARTp) which are anorexigenic compounds that lower food intake and ameliorate metabolic parameters connected with obesity, as well as improve neurodegeneration in brain upon peripheral administration. The synthesis of these lipidized peptides is described, as well as their pharmacological effects in vitro and in vivo.
Bibliography:Application Number: EP20220205680