COMPOSITION CONTAINING PEPTIDE COMPOUND AND SURFACTANT

• Main Authors: TAKANO, Ryusuke, TANG, Hengmin, NAKAE, Shinichi, SAKURAI, Yuji
• Format: Patent
• Language: English; French; German
• Published: 19.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

[Problem to be Solved]To provide a composition containing a peptide compound and a surfactant, having enhanced membrane permeability and/or absorbability of the peptide compound.[Solution]A composition containing components (1) and (2) below:(1) at least one or more peptide compounds selected from the group consisting of (i), (ii), and (iii) below:(i) a peptide compound containing one or more N-substituted amino acid residues,(ii) a peptide compound having ClogP between 4 and 25, and(iii) a peptide compound having a solubility of 10,000 µg/mL or less and exceeds 0 µg/mL in 50 mM phosphate buffer (pH 6.5) under the conditions of 37°C, 1 atm; and(2) at least one or more surfactants selected from the group consisting of (iv) and (v) below:(iv) a surfactant having a linear alkylene structure and having carbon atoms between 5 and 13 in the linear alkylene structure, and(v) a surfactant having a carnitine residue.