PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL]PYRIMIDIN-5-YL}CARBAMATE

The present application relates to a novel and efficient process with high yield for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl} carbamate of the formula (I)in the crystalline form of modification I in very high purity which is signific...

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Main Authors SOWA, Michal, FABER, Helene, BREMEYER, Nadine, BECKER, Guido, FEY, Peter, LONGERICH, Markus, NEUMANN, Heike, FRENZEL, Thomas, BROCKOB, Joerg
Format Patent
LanguageEnglish
French
German
Published 19.04.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present application relates to a novel and efficient process with high yield for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl} carbamate of the formula (I)in the crystalline form of modification I in very high purity which is significantly more cost-effective than the process known from the art and can be performed in customary pilot- and production plant-equipment (stirred tank/devices for isolation).
Bibliography:Application Number: EP20210732878