TREATMENT METHOD OF LEFT VENTRICULAR DYSFUNCTION FOLLOWING AN ACUTE MYOCARDIAL INFARCTION

The present invention refers to a composition comprising a compound capable of reducing the expression of the Yin Yang 1 (Yy1) gene in cardiac cells of a human or animal subject with respect to the expression observed in the absence of the compound in said cells, wherein the compound is an interfere...

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Bibliographic Details
Main Authors PASCUAL FIGAL, Domingo Andrés, LAX PÉREZ, Antonio Manuel, ASENSIO LÓPEZ, María Carmen
Format Patent
LanguageEnglish
French
German
Published 12.04.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention refers to a composition comprising a compound capable of reducing the expression of the Yin Yang 1 (Yy1) gene in cardiac cells of a human or animal subject with respect to the expression observed in the absence of the compound in said cells, wherein the compound is an interference RNA (RNAi) of the Yy1 gene, and wherein said compound is for use in the treatment of myocardial fibrosis, cardiac inflammation, cardiac hypertrophy and/or functional impairment 2 to 48 hours after acute myocardial infarction (AMI).
Bibliography:Application Number: EP20210730620