IMPROVED OLIGONUCLEOTIDE SYNTHESIS SUPPRESSING DEPURINATION

An improved protocol for the synthesis of oligonucleotides is provided. A liquid composition for the cleavage of a di(p-methoxyphenyl)phenylmethyl protecting group from a hydroxyl group and the use thereof in chemical synthesis of oligonucleotides is disclosed.

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Bibliographic Details
Main Authors SAMSON, Daniel, CREUSEN, Guido, BERTHELMANN, Arne, EISENHUTH, Ralf, HAUG, Karl Rüdiger
Format Patent
LanguageEnglish
French
German
Published 02.08.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:An improved protocol for the synthesis of oligonucleotides is provided. A liquid composition for the cleavage of a di(p-methoxyphenyl)phenylmethyl protecting group from a hydroxyl group and the use thereof in chemical synthesis of oligonucleotides is disclosed.
Bibliography:Application Number: EP20220711569