PHARMACEUTICAL FOR TREATING FATTY LIVER DISEASES

• Main Authors: SHIMAZAKI Atsuyuki, HAMADA Tadateru, YUKIOKA Hideo, OHYABU Naoki
• Format: Patent
• Language: English; French; German
• Published: 05.06.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

Provided is a pharmaceutical composition for treating and/or preventing fatty liver disease, particularly nonalcoholic fatty liver disease, the pharmaceutical composition having an excellent ACC2-selective inhibitory action and having no side effects such as an increase in plasma triglyceride or a decrease in platelet concentration.A pharmaceutical composition for treating and/or preventing fatty liver disease, the pharmaceutical composition comprising a compound represented by Formula (I):whereinR1 is haloalkyl or non-aromatic carbocyclyl,R2 is a hydrogen atom or halogen,R3 is halogen,ring A is a group represented by the formula: -L1- is -O-(CH2)-, -(CH2)2-, or the like,R4 is alkyl or haloalkyl, andR5 is alkylcarbonyl or carbamoyl,or a pharmaceutically acceptable salt thereof.