PHARMACEUTICAL FOR TREATING FATTY LIVER DISEASES

Provided is a pharmaceutical composition for treating and/or preventing fatty liver disease, particularly nonalcoholic fatty liver disease, the pharmaceutical composition having an excellent ACC2-selective inhibitory action and having no side effects such as an increase in plasma triglyceride or a d...

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Bibliographic Details
Main Authors SHIMAZAKI Atsuyuki, HAMADA Tadateru, YUKIOKA Hideo, OHYABU Naoki
Format Patent
LanguageEnglish
French
German
Published 05.06.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:Provided is a pharmaceutical composition for treating and/or preventing fatty liver disease, particularly nonalcoholic fatty liver disease, the pharmaceutical composition having an excellent ACC2-selective inhibitory action and having no side effects such as an increase in plasma triglyceride or a decrease in platelet concentration.A pharmaceutical composition for treating and/or preventing fatty liver disease, the pharmaceutical composition comprising a compound represented by Formula (I):whereinR1 is haloalkyl or non-aromatic carbocyclyl,R2 is a hydrogen atom or halogen,R3 is halogen,ring A is a group represented by the formula: -L1- is -O-(CH2)-, -(CH2)2-, or the like,R4 is alkyl or haloalkyl, andR5 is alkylcarbonyl or carbamoyl,or a pharmaceutically acceptable salt thereof.
Bibliography:Application Number: EP20210808650