TERPOLYMER AND POLYMER BRUSHES FOR USE AGAINST NON-SPECIFIC ADSORPTION OF SUBSTANCES FROM BIOLOGICAL MEDIA

• Main Authors: VISOVA, Ivana, HOUSKA, Milan, LISALOVA, Hana, DEJNEKA, Alexandr, VRABCOVA, Marketa
• Format: Patent
• Language: English; French; German
• Published: 13.12.2023
• Subjects: ADHESIVES; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL PAINT OR INK REMOVERS; CHEMISTRY; COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS; COMPOSITIONS BASED THEREON; CORRECTING FLUIDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; DYES; FILLING PASTES; HUMAN NECESSITIES; HYGIENE; INKS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC MACROMOLECULAR COMPOUNDS; PAINTS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; PHYSICS; POLISHES; TESTING; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF MATERIALS THEREFOR; WOODSTAINS

A random terpolymer of N-(2-hydroxypropyl) methacrylamide, carboxybetaine methacrylamide and sulfobetaine methacrylamide, and a polymer brush and to a functionalized polymer brush containing this terpolymer are disclosed. The random terpolymer increases the resistance of the substrate surface to non-specific adsorption of substances from biological media and/or to non-specific interaction with biological media components, and is suitable for use in the form of a polymer brush, for example in sensors or membranes.