FUSION PROTEINS COMPRISING ANTI C3B SINGLE DOMAIN ANTIBODY FOR COMPLEMENT REGULATION

The present application relates to a fusion protein comprising: a single domain antibody that binds to C3b; a polypeptide comprising or consisting of the amino acid sequence according to SEQ ID NO: 10, or a variant thereof having at least 80% sequence identity to the amino acid sequence according to...

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Bibliographic Details
Main Authors Rom Andersen, Gregers, Stub Laursen, Nick, Kjeldsen Jensen, Rasmus, Pedersen, Henrik
Format Patent
LanguageEnglish
French
German
Published 01.03.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present application relates to a fusion protein comprising: a single domain antibody that binds to C3b; a polypeptide comprising or consisting of the amino acid sequence according to SEQ ID NO: 10, or a variant thereof having at least 80% sequence identity to the amino acid sequence according to SEQ ID NO: 10; and a first linker. Furthermore is provided polypeptides, nucleic acids, vectors and methods of preparing these as well as methods of treatment and pharmaceutical compositions.
Bibliography:Application Number: EP20210193927