ARYL OR HETEROARYL DERIVATIVE

A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic...

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Main Authors MINAMIZONO, Kunio, HOSODA, Shinnosuke, SUGIYAMA, Sakae, JOHNSON, Brett M, MARUYAMA, Akinobu, ZHAO, Wei, KAWANA, Asahi, YOKOSAKA, Takuya, KANEKO, Toshiyuki, KATO, Kenta, TAKEUCHI, Susumu, CHAKKA, Nagasree, SASAKI, Kosuke, WHITE, Ryan d, KOSHIMIZU, Masaki
Format Patent
LanguageEnglish
French
German
Published 23.08.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar1, Ar2, X1-X3, R1, R3, R7, R8, L1, and L2 are as defined in the specifications.)
Bibliography:Application Number: EP20210789367