METHODS AND COMPOUNDS FOR THE ALLEVIATION AND/OR PREVENTION OF BONE LOSS AND/OR PAIN

• Main Authors: Malmström, Vivianne, Catrina, Anca, Klareskog, Lars, Svensson, Camilla
• Format: Patent
• Language: English; French; German
• Published: 08.02.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

Compounds capable of inhibiting the activity of peptidylarginine deiminase (PAD) enzymes (PAD inhibitors) can be used in the alleviation and/or prevention of bone loss and/or the alleviation of pain, said bone loss and/or pain being associated with an elevated activation of osteoclasts in a subject, and wherein the elevated activation of osteoclasts is associated with the presence of autoantibodies in the subject but wherein the subject does not manifest clinical signals of an autoimmune disease. Specific compounds are exemplified, for example amidine compounds, streptonigrin, 1,2,3-triazole peptidomimetic-based derivatives, and anti-peptidylarginine deiminase (PAD) antibodies. Also disclosed are diagnostic kits for identifying individuals that would benefit from a method of treatment for preventing and/or alleviating bone loss and/or alleviating pain in a subject wherein said bone loss and/or pain is associated with an elevated activation of osteoclasts in said subject.