A METHOD OF APPLYING OF TURMERIC ON HIERARCHICAL ZEOLITES WITH A METHOD OF ITS PHOTODYNAMIC RELEASE

• Main Authors: Feliczak-Guzik, Agnieszka, Musielak, Ewelina, Nowak, Izabela
• Format: Patent
• Language: English; French; German
• Published: 11.09.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The subject of the invention is a method of applying of turmeric on hierarchical zeolites possessing secondary porosity, pores in the range of 2-50 nm, synthesised on the basis of faujasite and with the use of ionic and non-ionic structure-forming agents, with a method for photo-dynamic release of turmeric from the hierarchical zeolite.A method of applying of turmeric on hierarchical zeolites possessing secondary porosity, pores in the range of 2-50 nm, synthesised on the basis of faujasite and non-ionic structure-forming agents: polyethyleneglycol octadecylisocyanate ether or Pluronic F127 and ionic structure-forming agents hexadecyltrimethylammonium bromide in the presence or absence of piperine, wherein to hierarchic zeolite obtained on the basis of faujasite type zeolite solvent is added, advantageously acetone in an amount of 2.5-12.5% w/w, advantageously 12.5% w/w in relation to hierarchical zeolite, 20-60% w/w advantageously 20% w/w of turmeric in relation to hierarchical zeolite, and 0.1-0.4% w/w, advantageously 0.1% w/w of piperidine in relation to hierarchical zeolite, whereas the entire process of mixing is conducted for 2-30 h advantageously 24 h in a temperature of 20-40°C advantageously in 23°C, and the obtained product is washed with a water-ethanol solution in a volumetric ration of 1:1 and dried afterwards.Afterwards, the material obtained in this manner is subjected to photodynamic release of turmeric. This process consists of adding phosphate buffer with a pH ranging from 5 to 6, advantageously 5.8 to hierarchical zeolite obtained from faujasite type zeolite with applied turmeric, with hierarchical zeolite with turmeric in an amount of 20% to 60% w/w, advantageously 60% w/w in relation to hierarchical zeolite, with the amount of buffer being 1:5, 1:10 and 1:15 by weight compared to hierarchical zeolite with applied turmeric, advantageously 1:10 by weight, and adding a penetration promoter in an amount of 5% to 25% w/w in relation to the buffer, with the process of releasing of turmeric from hierarchical zeolite is conducted for 0.5 to 30 h in a temperature of 35 to 43°C, advantageously 37°C with or without the use of UV-Vis in the wavelength range of 400 to 800 nm, advantageously from 200 to 800 nm in order to obtain the product. It is advantageous when the penetration promoter is glycerine or ethyl alcohol or Tween 80.