OLIGONUCLEOTIDES COMPRISING A PHOSPHOROTRITHIOATE INTERNUCLEOSIDE LINKAGE

The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I)wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament.

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Bibliographic Details
Main Authors LI, Meiling, DUSCHMALÉ, Joerg Jakob Andreas, SCHAEUBLIN, Adrian, BLEICHER, Konrad, KOCH, Troels, KOLLER, Erich, DUSCHMALÉ, Martina Brigitte
Format Patent
LanguageEnglish
French
German
Published 29.05.2024
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I)wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament.
Bibliography:Application Number: EP20220174461