MAGNOLOL AND SULFORAPHANE CONJUGATE, AND PREPARATION METHOD THEREFOR

Disclosed in the present invention are a magnolol and sulforaphane conjugate, and a preparation method and use thereof. The magnolol and sulforaphane conjugate comprises C25H29NO2S2(CT-1), C25H29NO4S2(CT-2), and C25H29NO3S2 (CT-3). By using the drug combination principle, the present invention achie...

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Bibliographic Details
Main Authors TAO, Cheng, WU, Zhengzhi, LI, Limin, LIU, Jieren, CHEN, Jian, ZENG, Yongchang
Format Patent
LanguageEnglish
French
German
Published 21.02.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed in the present invention are a magnolol and sulforaphane conjugate, and a preparation method and use thereof. The magnolol and sulforaphane conjugate comprises C25H29NO2S2(CT-1), C25H29NO4S2(CT-2), and C25H29NO3S2 (CT-3). By using the drug combination principle, the present invention achieved the first synthesis of the magnolol and sulforaphane conjugate (CT-1, CT-2, CT-3). According to biological evaluation, the conjugate has an antitumor effect remarkably superior to that of magnolol and sulforaphane, has a broad spectrum of antitumor activity and strong druggability. It is an antitumor compound with development potential, and also provides new ideas and approaches for development of a novel antitumor drug.
Bibliography:Application Number: EP20200908276