METHODS FOR IDENTIFYING MODULATORS OF INSECT TRANSIENT RECEPTOR POTENTIAL CHANNELS

• Main Authors: KANDASAMY, Ramani, STAM, Lynn, F, NESTEROV, Alexandre
• Format: Patent
• Language: English; French; German
• Published: 03.07.2024
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PEST REPELLANTS OR ATTRACTANTS; PHYSICS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TESTING; TRAPPING

The present invention relates to a screening method for determining whether or not a candidate compound is a modulator of a complex consisting of the insect transient receptor potential channel Nanchung protein and the insect transient receptor potential channel Water witch protein. The present invention further relates to a screening method for determining whether or not a candidate compound directly binds to the complex consisting of the Nanchung protein and Water witch protein. The present invention further relates to a screening method for determining whether or not a candidate compound is a modulator of the insect Water witch protein. The present invention further provides a method of insect control by applying an insect-specific TRP channel modulator determined by the screening method. The present invention further provides a method of classifying an insecticide compound by its mode of action using the binding assay and/or a functional assay.