SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES

• Main Authors: LI, Kangying, THURING, Johannes Wilhelmus John F, DARVILLE, Nicolas Freddy J, DAI, Xuedong, XU, Yanping, FANG, Lichao, FU, Liqiang, NG, Alicia Tee Fuay, URBANIETZ, Gregor Thomas, DENG, Xiangjun, MATON, William, Marc, ZHAO, Qiwu, LIU, Yingtao, PANDE, Vineet, CAI, Wei, QUEROLLE, Olivier Alexis Georges, CLEATOR, Edward, LIU, Lianzhu, LI, Ming
• Format: Patent
• Language: English; French; German
• Published: 26.10.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.