METHOD FOR PRODUCING PEPTIDE CONTAINING NON-NATURAL AMINO ACID

The present invention revealed that translating an mRNA that encodes a peptide containing an unnatural amino acid in a translation system that contains a ribosome containing an engineered L31 protein can increase the amount of the translated peptide. Furthermore, the invention revealed that by using...

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Bibliographic Details
Main Authors YOSHII, Sakiko, SHIMOMURA, Koichiro, ISHINO, Sou
Format Patent
LanguageEnglish
French
German
Published 10.01.2024
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Summary:The present invention revealed that translating an mRNA that encodes a peptide containing an unnatural amino acid in a translation system that contains a ribosome containing an engineered L31 protein can increase the amount of the translated peptide. Furthermore, the invention revealed that by using this ribosome, the relative amount of by-products can also be reduced. An engineered L31 protein of the present invention has an amino acid sequence with deletion of 6 or more amino acid residues from the C terminus in the amino acid sequence of the wild-type Escherichia coli L31 protein.
Bibliography:Application Number: EP20200899836