PROCESS FOR THE PREPARATION OF LASMIDITAN AND OF A SYNTHESIS INTERMEDIATE

A process for the preparation of Lasmiditan and of a synthesis intermediate of formula (II):including reacting a compound of Formula (III)wherein X and Y, each independently, represent a halogen atom, with an aqueous solution of ammonia, in presence of at least one bidentate ligand and of at least o...

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Main Authors INVERNIZZI, Christian, CREMONESI, Giuseppe, BERTOLINI, Giorgio, SADA, Mara, FELICIANI, Lazzaro
Format Patent
LanguageEnglish
French
German
Published 17.04.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for the preparation of Lasmiditan and of a synthesis intermediate of formula (II):including reacting a compound of Formula (III)wherein X and Y, each independently, represent a halogen atom, with an aqueous solution of ammonia, in presence of at least one bidentate ligand and of at least one copper-based catalyst, and optionally converting the so-obtained compound of Formula (II) into a salt and/or solvate thereof.
Bibliography:Application Number: EP20200830326