OPTICAL METHOD FOR DETECTING A TARGET MOLECULE BY MEANS OF THE AMPLIFICATION IN THE INTERFERENCE RESPONSE, RESULTING FROM THE REFRACTIVE INDEX AND DISPERSION

The invention relates to an optical method for detecting at least one target molecule (TM) contained in a sample at a determined concentration, which comprises: (a) bringing a sample containing the TM into contact, in a liquid medium, with a solution containing nanoparticles (NPs), the surface of th...

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Main Authors HOLGADO BOLAÑOS, Miguel, GARRIDO ARANDIA, María, RAMÍREZ ALONSO, Yolanda, LÓPEZ ESPINOSA, Rocío, FERNÁNDEZ PACIOS, Luis, SANZA GUTIÉRREZ, Francisco Javier, SANTAMARÍA FERNÁNDEZ, Beatriz, DÍAZ PERALES, Araceli, ROMERO SAHAGÚN, Alejandro, LAGUNA HERAS, María Fe
Format Patent
LanguageEnglish
French
German
Published 27.12.2023
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The invention relates to an optical method for detecting at least one target molecule (TM) contained in a sample at a determined concentration, which comprises: (a) bringing a sample containing the TM into contact, in a liquid medium, with a solution containing nanoparticles (NPs), the surface of the NPs having been coated or functionalised with at least one type of specific bioreceptor (BR) of the target molecule to be detected (NP-BR), such that the BRs specifically recognise the TM, thus forming conjugates of the NP-BRs with the TMs (NP-BR-TMs); (b) separating the nanoparticles conjugates (NP-BR-TMs and/or NP-BRs) formed in the previous
Bibliography:Application Number: EP20200895200