PROCESS FOR THE PREPARATION OF CORTEXOLONE 17 A-PROPIONATE AND NEW HYDRATED CRYSTALLINE FORM THEREOF

The present invention is directed to a process for the preparation of cortexolone 17α-propionate, comprising a hydrolysis reaction of an ortho-ester of formula (III)in which R is a hydrogen atom or a methyl group,in the presence of a dilute solution of acetic acid.The present invention is also direc...

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Bibliographic Details
Main Authors Di Giacomo, Mario, Arosio, Roberto, Ponzinibi, Matteo, Brusasca, Marco
Format Patent
LanguageEnglish
French
German
Published 12.10.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The present invention is directed to a process for the preparation of cortexolone 17α-propionate, comprising a hydrolysis reaction of an ortho-ester of formula (III)in which R is a hydrogen atom or a methyl group,in the presence of a dilute solution of acetic acid.The present invention is also directed to a hydrated crystalline form of cortexolone 17a-propionate obtained by such process.
Bibliography:Application Number: EP20220152647