MRNA CONSTRUCT FOR PROTEIN EXPRESSION, AND USE THEREOF

The present invention relates to an mRNA or mRNA construct including: (a) a region encoding a protein or peptide of interest; (b) a β-globin UTR region at the 5'end; and (c) a region at the 3'end in which BGH, BGH-IRES, or IRES-BGH is inserted. An mRNA or mRNA construct according to the pr...

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Bibliographic Details
Main Authors CHOI, In Pyo, KIM, Tae Don, KANG, Hee Young
Format Patent
LanguageEnglish
French
German
Published 14.06.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to an mRNA or mRNA construct including: (a) a region encoding a protein or peptide of interest; (b) a β-globin UTR region at the 5'end; and (c) a region at the 3'end in which BGH, BGH-IRES, or IRES-BGH is inserted. An mRNA or mRNA construct according to the present invention improves intracellular expression or expression stability, and intracellular persistence of a chimeric antigen receptor or chimeric antigen receptor protein (CAR protein). In addition, the mRNA or mRNA construct increases the in vivo safety of the chimeric antigen receptor, and increases the ability thereof to kill cancer cells, and thus can be effectively used in anticancer pharmaceutical compositions and anticancer immunotherapy targeting solid tumors.
Bibliography:Application Number: EP20200893955