REINFORCED ENGINEERED BIOMATERIALS AND METHODS OF MANUFACTURE THEREOF

• Main Authors: JAKAB, Karoly, Robert, PURCELL, Brendan, Patrick, FORGACS, Gabor
• Format: Patent
• Language: English; French; German
• Published: 05.10.2022
• Subjects: APPARATUS THEREFOR; BEER; BIOCHEMISTRY; CHEMICAL TREATMENT OF HIDES, SKINS OR LEATHER, e.g. TANNING,IMPREGNATING, FINISHING; CHEMISTRY; COMPOSITIONS FOR TANNING; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR; FLEXIBLE SHEET MATERIAL NOT OTHERWISE PROVIDED FOR; HIDES; LAUNDERING; LEATHER; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PELTS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SKINS; SPIRITS; TEXTILES; TREATMENT OF TEXTILES OR THE LIKE; VINEGAR; WALL, FLOOR OR LIKE COVERING MATERIALS, e.g. LINOLEUM,OILCLOTH, ARTIFICIAL LEATHER, ROOFING FELT, CONSISTING OF AFIBROUS WEB COATED WITH A LAYER OF MACROMOLECULARMATERIAL; WINE

Reinforced engineered biomaterials, and methods of making them, may be useful to form engineered leathers. Such engineered hides may be reinforced by encapsulating, and/or cross-linking to, a mesh and/or scaffold material, which may be a synthetic polymeric material. The resulting hide may include a stratified structure in which the mesh is held between layers of collagen-dense regions, where the collagen-dense regions overlaying the mesh following the contour of the mesh. Alternatively or additionally, the resulting hide may be a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells. These engineered leathers may be referred to as fiber-reinforced biological tissue composites. The resulting materials may have superior durability and flexibility compared to other engineered materials and native leather, while retaining the look and feel of native leather.