GLP-1 RECEPTOR AGONIST AND USE THEREOF

The present invention provides novel compounds of chemical formula 1, optical isomers of the compounds, or a pharmaceutically acceptable salts of the compounds, or the optical isomers. The compounds, isomers, and salts exhibits excellent activity as GLP-1 receptor agonists. Particularly, they, as GL...

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Bibliographic Details
Main Authors KIM, Jung Ho, JE, In-gyu, JEON, Woo Jin, IM, A-rang, SHIN, Jae Eui, CHANG, Min Whan, KIM, Kyeojin, KIM, Jeong-geun, JEONG, Jin Ah, KWON, Sung Wook, LEE, Jin Hee, JANG, Eun Hye, LEE, Myong Jae, SOHN, Te-ik, OH, Changmok, HONG, Changhee, HONG, Da Hae, KIM, Gunhee, PARK, Jung-eun, CHOI, Ji Hye, HEO, Jaeho, YOO, Yeongran, AN, Kyung Mi, JUN, Yearin, YOON, Hong Chul
Format Patent
LanguageEnglish
French
German
Published 01.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides novel compounds of chemical formula 1, optical isomers of the compounds, or a pharmaceutically acceptable salts of the compounds, or the optical isomers. The compounds, isomers, and salts exhibits excellent activity as GLP-1 receptor agonists. Particularly, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used therapeutic agents for metabolic diseases. In addition, they exhibits excellent pharmacological safety for cardiovascular systems.
Bibliography:Application Number: EP20200887271